Synthesis of α-Methylated Amino Acids for Buchwald-Hartwig Cross-Coupling

Authors

  • Si Trung Dung Phan University of Ottawa, Ottawa, ON, Canada
  • Kyle D. Passley University of Ottawa, Ottawa, ON, Canada
  • Michael G. Organ University of Ottawa, Ottawa, ON, Canada

DOI:

https://doi.org/10.18192/osurj.v5i2.8055

Abstract

α-Methylated amino acids are valuable components in peptide drugs due to their ability to protect
peptides from enzymatic degradation. The objective of this work was to demonstrate that an α
methylated amino acid, bearing an alkyl amine side chain, could undergo cross-coupling with an
aryl halide via Buchwald-Hartwig amination. Progress has been made toward the synthesis of these
amino acids from N-benzyloxycarbonyl-D-alanine.

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Published

2026-06-17

Issue

Vol. 5 No. 2 (2026)

Section

Undergraduate Science Research Opportunity Abstracts

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