Do stem cell divisions significantly contribute to cancer development?
DOI :
https://doi.org/10.18192/osurj.v1i1.3687Résumé
Le cancer est causé par une croissance cellulaire incontrôlée, pourtant certaines cellules cancéreuses peuvent jouer un rôle plus important dans le maintien de la prolifération tumorale et peuvent aider à surmonter les traitements conventionnels contre le cancer. Les origines de ces cellules souches cancéreuses, telles quelles, sont largement contestées. Actuellement, on souligne des facteurs extrinsèques tels que le tabagisme, l’alimentation et le mode de vie sédentaire comme principaux inducteurs des cellules souches cancéreuses. Ce dogme a été contesté en 2015 lorsque Tomasetti et Vogel stein ont postulé que les deux tiers de la variation du risque de cancer pouvaient être expliqués par des mutations aléatoires survenant lors de la réplication de l’ADN dans des cellules souches saines. Leur hypothèse de « malchance » a suscité de vifs débats et controverses dans la communauté scientifique. Dans cet article point-contrepoint, nous discutons du modèle de cellules souches cancéreuses à mutation aléatoire et de ses implications pour guider la santé publique à travers la prévention primaire et secondaire du cancer.
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