Comparison of regenerative neurogenesis in response to CNS injury between adult zebrafish and mice
DOI :
https://doi.org/10.18192/osurj.v1i1.3696Résumé
La différence entre le poisson zèbre adulte et les souris quant à leur capacité de régénération après une lésion du système nerveux central (SNC) est influencée par la permissivité du microenvironnement du cerveau, mis à part le potentiel neurogène intrinsèque de la population cellulaire. Chez le poisson zèbre adulte, les cellules gliales conservent en grande partie leurs caractéristiques radiales et leur capacité neurogène. De plus, le cerveau du poisson zèbre démontre un rétablissement complet après une lésion cérébrale traumatique (LCT) et une lésion de la moelle épinière (LME). Inversement, chez les souris, les cellules gliales se différencient en astrocytes. En excluant certaines régions du cerveau, après une LCT, les astrocytes réactifs qui ont le potentiel de devenir des cellules souches neurales (CSN) in vitro demeurent strictement non-neurogènes in vivo, en raison de facteurs inhibiteurs
présents dans le microenvironnement. Combinée avec une inflammation prolongée et une gliose, une lésion du SNC aboutit finalement à la formation d’une cicatrice gliale qui entrave encore la régénération. Cependant, chez les rongeurs, la suppression de la neurogenèse peut constituer un mécanisme de protection contre les effets éventuels de la neurogenèse à long terme.
Téléchargements
Publié-e
Numéro
Rubrique
Licence
OSURJ Publication Rights Policy Agreement Please fill in the following blanks.
I, ____________________ (submitting author) am submitting an article to the University of Ottawa Science Undergraduate Research Journal (OSURJ) entitled _________________________________________________________________________
I. OSURJ Mandate:
The University of Ottawa Science Undergraduate Research Journal is a bilingual multidisciplinary open-access and non-proprietary journal. A journal of this nature embraces all disciplines of science and is the result of a collaborate effort between undergraduate, graduate and faculty members. Our goal is to provide invaluable publishing and submission process experience to undergraduate students and ultimately promote undergraduate research within the UOttawa community.
II. Review Process of OSURJ
OSURJ uses a single-blind review process. The submitted article is first sent to the managing editor who assigns the article to the relevant section editor responsible for the specific science discipline. The section editor provides a preliminary review to confirm that the submission is within OSURJ’s scope after which it is assigned to one undergraduate reviewer and one faculty review for independent review. The reviewers recommend to either reject, accept or conditionally accept the article with revisions required. Based on the recommendations from both reviewers, the section editor makes the final decision of publication.
III. Proprietorship and Author Rights:
Authors retain all copyrights to their research and original data and may publish in other journals at the journal’s discretion. OSURJ acknowledges that all information submitted by the author(s) is their intellectual property and therefore any republication of such property is not allowed without written consent from the submitting author(s). Articles published in OSURJ may be published in other journals.
However authors should be made aware that other publishers may not permit the republication of original research published in an undergraduate journal such as OSURJ. Consequently, the author should consult the publication policies of other journals, and all relevant parties should be made aware of this possibility before proceeding with article submission.
IV. Falsification of Data
Methods for the acquisition and analysis of data should be accurately and fully displayed to allow for replication by other researchers. Data fabrication and alteration is unethical and may lead to unfounded conclusions. As such, it is not permitted by OSURJ.
V. Permission from All Contributors:
Given that research is collaboratively conducted with professors and other students, OSURJ requires that all contributors (co-authors, primary investigators, lab managers, supervisors) consent to the submission of the article to OSURJ.
Any person listed as an author of an article must have contributed greatly to the data, analysis or interpretation of said data and should provide approval of the submitted version. It is unethical to not list those who contributed to the standards of an author and to include those who do not meet the criteria for authorship.
For articles with multiple authors, primary, secondary (etc.) author status must also be agreed upon.
