Novel hybrid biofilm system using synthetically engineered curli fibres
DOI :
https://doi.org/10.18192/osurj.v1i1.3708Résumé
La fracturation hydraulique, technique d’extraction populaire, génère une contamination par les métaux lourds dans les aquifères d’eau douce situés à proximité. Cela constitue une menace à la fois pour les écosystèmes environnants et pour la santé humaine. Les méthodes actuelles d’élimination des métaux lourds peuvent produire des sous-produits dangereux supplémentaires. Cette proposition présente l’utilisation d’un filtre à biofilm hybride contenant du graphène et des fibres de curli avec des sites de liaisons métalliques. Les fibres de curli sont des fibrilles amyloïdes retrouvées sur le biofilm extracellulaire d’Escherichia coli (E coli.). Grâce à l’utilisation de vecteurs plasmidiques, l’E. coli sera manipulé pour produire des fibres de curli sécrétées avec des résidus de liaison aux métaux. La stabilité et les propriétés cohésives des fibres de curli augmentent l’adhérence à l’échafaudage de graphène, permettant ainsi la génération d’un biofilm hybride. Avec la conception de la filtration et les différents contrôles expérimentaux proposés, ce modèle est prêt pour la validation empirique du concept et l’optimisation quantitative subséquente.
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