Genetics and Medicine Collaborative Effort: Can targeted genetic testing aid in early disease detection and improve patient outcomes?
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Published:
Apr 17, 2021
Keywords:
arthritis; diabetes; genetic screening; mental health disorders; multifactorial; preventative medicine
Main Article Content
Abstract
An increasing attention on preventative medicine promises to remodel healthcare by using proactive approaches designed to avert and avoid potential diseases from being introduced to the patient. Genetic screening is a subset of health program measures that is purposely designed to be offered to asymptomatic individuals in favour for providing promising forms of early treatment. Whilst many diseases are multifactorial in nature, an early detection of the disorder can aid in tailoring effective medical interventions to the patient. This article will discuss implementing early genetic screening with the aim to promote greater collaboration between the field of genetics and medicine.
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2. Ali O. Genetics of type 2 diabetes. World J Diabetes. 2013 Aug 15;4(4):114–123.
3. Clausen JO, Hansen T, Bjørbaek C et al. Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1. Lancet. 1995 Aug 12;346(8972):397-402.
4. Le Fur S, Le Stunff C, Bougnères P. Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms. Diabetes. 2002 Dec;51 Suppl 3:S304-7.
5. Bilandzic A, Rosella L. The cost of diabetes in Canada over 10 years: applying attributable health care costs to a diabetes incidence prediction model. Health Promot Chronic Dis Prev Can. 2017 Feb;37(2):49-53.
6. Evans JP, Skrzynia C, Burke W. The complexities of predictive genetic testing. BMJ. 2001 Apr 28;322(7293):1052-6.
7. John M. Eisenberg Center for Clinical Decisions and Communications Science. Medicines for Rheumatoid Arthritis: A Review of the Research for Adults. In: Comparative Effectiveness Review Summary Guides for Consumers [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2005- [cited 2018 Apr 15]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK115126/.
8. Jawaheer D, Thomson W, MacGregor AJ et al. "Homozygosity" for the HLA-DR shared epitope contributes the highest risk for rheumatoid arthritis concordance in identical twins. Arthritis Rheum. 1994 May;37(5):681-6.
9. Kurkó J, Besenyei T, Laki J, Glant TT, Mikecz K, Szekanecz Z. Clin Rev Allergy Immunol. 2013 Oct;45(2):170-9.
10. Nichols H. What are the causes and types of arthritis? Medical News Today [Internet]. 2017 Nov 14 [cited 2018 June 27]:A17. Available from: https://www.medicalnewstoday.com/articles/7621.php
11. Demkow U, Wolańczyk T. Genetic tests in major psychiatric disorders-integrating molecular medicine with clinical psychiatry-why is it so difficult? Transl Psychiatry. 2017 Jun 13;7(6):e1151.
12. Mundo E, Kennedy JL. Genetics of Mental Disorders. J Psychiatry Neurosci. 2002;27(4):291-292.