Implications of Striatal Dopamine Signalling for Schizophrenia

Authors

  • Alexander Simmons a:1:{s:5:"en_US";s:41:"University of Ottawa, Faculty of Medicine";}

DOI:

https://doi.org/10.18192/uojm.v10i2.4876

Keywords:

Schizophrenia, Striatum, Dopamine Signalling, Optogenetics

Abstract

Our understanding of striatal dopamine (DA) function has come a long way since the inception of the DA hypothesis of schizophrenia. These advances have been facilitated in large part by the technique of optogenetics and they have helped to provide a neural basis for the motivational-salience theory of psychosis. This research has also revealed novel therapeutic targets for the treatment of schizophrenia. Optogenetic studies of striatal DA signalling have proven to be a promising area of research with important implications for our understanding of schizophrenia and its treatment. 

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Published

2021-04-17

Issue

Vol. 10 No. 2 (2021): Fall/Winter 2020-2021

Section

Commentary

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