The University of Ottawa Faculty of Medicine was pleased to virtually host the 2021 edition of its annual Research Day on September 24, 2021. 18 oral presentations and more than 200 posters were shared with the research community of the University, in English and French. Among these, 62 abstracts have been published in the present conference proceeding, at the authors’ discretion. We invite you to peruse this special issue of the University of Ottawa Journal of Medicine that highlights the amazing research conducted at the Faculty of Medicine!